Informatics Publishing Limited

Harpreet Singh ¹, Shekhar Verma ¹, Gaganpreet Kaur Marwah ¹

Affiliations
1 Department of Electronics and Communication Engineering, Lovely Professional University Phagwara - 144411, Punjab, IN

Abstract

Magnetic resonance imaging is most widely used radiographic technique in diagnosis, clinical research and studies as well as treatment planning of major diseases. Generally GLCM and PCA technique are used for the feature extraction and classification but this technique increased the complexity and it’s robust in nature. In this paper we used the Gabor filter with wavelet transformation classification technique for analyzing Magnetic response images. In this paper, the detection of abnormality in the patient’s image is automatically recognized using texture analysis. The hybrid technique may work as an automatic classification of abnormalities in lungs MRI images, which can help radiologist in performing an in-depth examination. The texture analyses of both the normal and abnormal images are done. On the bases of the values of abnormal images, the range is calculated and further it is compared with the texture features of normal image. So, to determine the whether the abnormality is there or not in the image, its texture features are observed and the feature lying outside the range finally concludes that image is normal. Five cases are observed, on the bases of their comparison, the result is obtained at the end indicating the whether the presence of abnormality in the image.

Keywords

Gabor Filter, Feature Extraction, Magnetic Response Images, Texture Classification

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Mohinder Bassi ¹, Shekhar Verma ¹, Rupendeep Kaur ²

Affiliations
1 Department of Electronics and Communication Engineering, Lovely Professional University Phagwara - 144411, Punjab, IN
2 2Department of Electronics and Communication Engineering, Guru Nanak Dev University Amritsar - 143005, Punjab, IN

Abstract

Background: Multiplier is very important block which is being used in number of devices like DSP processor and microprocessors. Power consumption by multipliers decides the battery life of all these devices. Researchers are continuously striving for the multiplier which consumes less power but as the most dominant technology till now is CMOS, their efforts are not giving fruitful results due to physical constraints of CMOS device. Methods: In the proposed design used a reversible computing methodology and for circuit designing of multiplier used a QCA Cells. Findings: By combination of reversible computing and ancient Vedic method, a low power and high speed multiplier is proposed. Improvements: With this proposed technique, the Garbage outputs are reduced by 25%, numbers of gates are reduced by 5.40%, numbers of constant inputs are reduced by 6.89%, Quantum cost is reduced by 7.89% and TRLIC factor of this vedic multiplier is reduced by 16.89%.

Keywords

Reversible Logi, Quantum Cost, Urdhva Triyag Sutra, Vedic, VLSI

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Misbah Manzoor ¹, Shekhar Verma ², Tapsi Singh ², Mahwash Manzoor ²

Affiliations
1 Department of Electronics and Communication Engineering, SSM College of Engineering, Srinagar - 191111, Jammu and Kashmir, IN
2 Department of Electronics and Communication Engineering, Lovely Professional University, Phagwara - 144411, Punjab, IN

Abstract

The advent of dynamic logic especially domino logic has made the use of dynamic circuits very wide for the implementation of low power VLSI circuits. Dynamic logic style is becoming the designers' choice these days because it has very fast speed and occupies very small area. In this paper we have used various techniques based on domino logic to overcome noise. Each technique has its merits and demerits. Out of these techniques mentioned below we have taken two widely used techniques in domino logic, conditional keeper technique and diode footed domino. We calculated their noise margins at different values of supply voltage. We have done simulations in 90 nm technology. After calculations we found both techniques show fairly good noise immunity but diode footed domino gave better results.

Keywords

Delay, Diode Footed Domino, Immunity, Leakage Tolerance, Noise, Power Consumption, Subthreshold Voltage, Technology Scaling.

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Shiba S. Morris ¹, G. Jeyabalan ¹, A. K. Jha ², Shekhar Verma ², Yashwant Swarnkar ²

Affiliations
1 Department of Pharmacy, Sunrise University, Alwar-301001 Rajasthan, IN
2 SSTC, Junwani, Bhilai-490020, Chattisgarh, IN

Abstract

The present research aimed at the in-vitro study of the anthelmintic activity of aqueous and ethanolic extracts of seeds of Carum carvi using Indian adult earthworms (Pheretima posthuma) at two different concentrations (10 and 20 mg/ml) in two different volumes 10ml and 15ml respectively. The study involved the determination of the time of paralysis and time of death of the worms. At the concentration of 20mg/ml in both volume i.e. 10ml and 15ml the Ethanolic extracts showed very significant activities as compared to the standard drug Albendazole at two different concentrations (10 and 20 mg/ml) volume taken 15ml. Ethanolic extract gives more effective result than aqueous extract when compare to standard. But aqueous extract also shows anthelmintic activity. In conclusion, aqueous and ethanolic extracts of seeds of Carum carvi as an anthelmintic have been confirmed and further studies are suggested to discover the active principles responsible for the activity.

Keywords

Carum carvi, Phytochemical, Anthelmintic, Pheretima posthuma, Albendazole.

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Domendra Sahu ¹, Shekhar Verma ², Ravindra D. Dubey ²

Affiliations
1 Institute of Pharmacy, RITEE, Raipur, (Chhattisgarh), IN
2 Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur, Chhattisgarh, IN

Abstract

The attractiveness of these dosage forms is due to awareness to toxicity and ineffectiveness of drugs when administered or applied by conventional method in the form of tablets, capsules, injections, ointments etc. usually conventional dosage form produces wide ranging fluctuation in drug concentration in the blood stream and tissues with consequent undesirable toxicity and poor efficiency. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of controlled delivery system. The goal in designing sustained or controlled delivery system is to reduce the frequency of the dosing or to increase effectiveness of the drug by localization at the site of action, reducing the dose required or providing uniform drug delivery. Tolperisone hydrochloride is a centrally acting muscle relaxant that has used for symptomatic treatment of spasticity and muscle pain, with half-life of 2.5-3 hours and requires multiple daily doses to maintain adequate plasma concentrations, so it is selected to prepare a sustained release tablets. The objective of this present study to develop a competitive sustained release tablets of Tolperisone Hydrochloride which releases the drug in a sustained manner over a period of 24 hours, by using different polymer and study on there effect on release pattern.

Keywords

Tolperisone Hydrochloride, Sustained, Muscle Relaxant, Spasticity.

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Pradeep Sahu ¹, Munglu Matlam ¹, Ravindra Dhar Dubey ¹, Shweta Paroha ², Shilpi Chatterji ¹, Shekhar Verma ¹, Tanushree Chatterjee ¹

Affiliations
1 Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur, Chhattisgarh, IN
2 Siddhi Vinayaka Institute of Technical Sciences, Mangla, Bilaspur, Chhattisgarh, IN

Abstract

The use of and search for drugs and dietary supplements derived from plants have accelerated in recent years. Ethno pharmacologists, botanists, microbiologists, and natural-products chemists are combing the Earth for phytochemicals and “leads” which could be developed for treatment of infectious diseases. While 25 to 50% of current pharmaceuticals are derived from plants. Traditional healers have long used plants to prevent or cure infectious conditions; Western medicine is trying to duplicate their successes. Plants are rich in a wide variety of secondary metabolites, such as tannins, terpenoids, alkaloids, and flavonoids, which have been found in vitro to have antimicrobial properties. This review attempts to summarize the current status of botanical screening efforts, as well as in vivo studies of their effectiveness and toxicity. The structure and antimicrobial properties of phytochemicals viz; Simple phenols and phenolic acids (spp.2) Quinones (spp.3) Flavones, flavonoids, and flavonol (spp.3), Tannins (spp.7) coumarins, (spp.1), Terpenoids and Essential Oils (spp.19), Alkaloids (spp.9) Lectins and polypeptides (spp.5) ,mixture (spp.4), other compounds (spp.1) and new antimicrobial plant origins (spp.7) are also addressed. Since many of these compounds are currently available as unregulated botanical preparations and their use by the public is increasing rapidly, clinicians need to consider the consequences of patients self-medicating with these preparations.

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Pradeep Sahu ¹, Munglu Matlam ¹, Ravindra Dhar Dubey ¹, Shweta Paroha ², Shilpi Chatterji ¹, Shekhar Verma ¹, Tanushree Chatterjee ¹

Affiliations
1 Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur, Chhattisgarh, IN
2 Siddhi Vinayaka Institute of Technical Sciences, Mangla, Bilaspur, Chhattisgarh, IN

Abstract

The use of and search for drugs and dietary supplements derived from plants have accelerated in recent years. Ethno pharmacologists, botanists, microbiologists, and natural-products chemists are combing the Earth for phytochemicals and "leads" which could be developed for treatment of infectious diseases. While 25 to 50% of current pharmaceuticals are derived from plants. Traditional healers have long used plants to prevent or cure infectious conditions; Western medicine is trying to duplicate their successes. Plants are rich in a wide variety of secondary metabolites, such as tannins, terpenoids, alkaloids, and flavonoids, which have been found in vitro to have antimicrobial properties. This review attempts to summarize the current status of botanical screening efforts, as well as in vivo studies of their effectiveness and toxicity. The structure and antimicrobial properties of phytochemicals viz; Simple phenols and phenolic acids (spp.2) Quinones (spp.3) Flavones, flavonoids, and flavonol (spp.3) , Tannins (spp.7) coumarins, (spp.1), Terpenoids and Essential Oils (spp.19), Alkaloids (spp.9) Lectins and polypeptides (spp.5) ,mixture (spp.4), other compounds (spp.1) and new antimicrobial plant origins (spp.7) are also addressed. Since many of these compounds are currently available as unregulated botanical preparations and their use by the public is increasing rapidly, clinicians need to consider the consequences of patients self-medicating with these preparations.

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Alok Pandey ¹, Shekhar Verma ², Ravindra Dhar Dubey ², Dhansay Dewangan ¹, Vidyanand Patel ², Keshav Deshmukh ²

Affiliations
1 Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52, Tamilnandu, IN
2 Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur - 492101 (C.G.), IN

Abstract

Schiff Bases of 2-amino-5-aryl-1, 3, 4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1, 3, 4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and ¹H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against Swiss albino mice, anti-inflammatory activity against Wister albino rats.

Keywords

Schiff base, 1, 3, 4-Thiadiazole, Analgesic, Anti-Inflammatory Activity.

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